The role of homologous recombination repair in the formation of chromosome aberrations

被引：26

作者：

Griffin, CS ^{[1
]}

Thacker, J ^{[1
]}

机构：

[1] MRC, Radiat & Genome Stabil Unit, Harwell OX11 0RD, Oxon, England

来源：

CYTOGENETIC AND GENOME RESEARCH | 2004年 / 104卷 / 1-4期

关键词：

D O I：

10.1159/000077462

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The repair of DNA double strand breaks by homologous recombination can occur by at least two pathways: a Rad51-dependent pathway that is predominantly error free, and a Rad51-independent pathway (single strand annealing, SSA) that is error prone. In theory, chromosome exchanges can result from (mis)repair by either pathway. Both repair pathways will involve a search for homologous sequence, leading to co-localization of chromatin. Genes involved in homologous recombination repair (HRR) have now been successfully knocked out in mice and the role of HRR in the formation of chromosome exchanges, particularly after ionising radiation, is discussed in the light of new evidence. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：21 / 27

页数：7

共 70 条

[1] Mouse models to study the role of telomeres in cancer, aging and DNA repair [J].

Blasco, MA .

EUROPEAN JOURNAL OF CANCER, 2002, 38 (17) :2222-2228

[2] The dynamic nuclear redistribution of an hnRNP K-homologous protein during Drosophila embryo development and heat shock. Flexibility of transcription sites in vivo [J].

Buchenau, P ;

Saumweber, H ;

ArndtJovin, DJ .

JOURNAL OF CELL BIOLOGY, 1997, 137 (02) :291-303

[3] Collisions between yeast chromosomal loci in vivo are governed by three layers of organization [J].

Burgess, SM ;

Kleckner, N .

GENES & DEVELOPMENT, 1999, 13 (14) :1871-1883

[4] Somatic pairing of homologs in budding yeast: existence and modulation [J].

Burgess, SM ;

Kleckner, N ;

Weiner, BM .

GENES & DEVELOPMENT, 1999, 13 (12) :1627-1641

[5] The formation of UV-induced chromosome aberrations involves ERCC1 and XPF but not other nucleotide excision repair genes [J].

Chipchase, MD ;

Melton, DW .

DNA REPAIR, 2002, 1 (04) :335-340

[6] Chromosomes are predominantly located randomly with respect to each other in interphase human cells [J].

Cornforth, MN ;

Greulich-Bode, KM ;

Loucas, BD ;

Arsuaga, J ;

Vázquez, M ;

Sachs, RK ;

Brückner, M ;

Molls, M ;

Hahnfeldt, P ;

Hlatky, L ;

Brenner, DJ .

JOURNAL OF CELL BIOLOGY, 2002, 159 (02) :237-244

[7] TESTING THE NOTION OF THE ONE-HIT EXCHANGE [J].

CORNFORTH, MN .

RADIATION RESEARCH, 1990, 121 (01) :21-27

[8] Historical overview: Searching for replication help in all of the rec places [J].

Cox, MM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (15) :8173-8180

[9] Kinetics of the formation of chromosome aberrations in X-irradiated human lymphocytes, using PCC and FISH [J].

Darroudi, F ;

Fomina, J ;

Meijers, M ;

Natarajan, AT .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1998, 404 (1-2) :55-65

[10]

Deans B, 2003, CANCER RES, V63, P8181

← 1 2 3 4 5 6 7 →