Evaluation of pulse corticosteroid therapy for Vogt-Koyanagi-Harada disease assessed by optical coherence tomography.

被引：45

作者：

Yamanaka, E ^{[1
]}

Ohguro, N ^{[1
]}

Yamamoto, S ^{[1
]}

Nakagawa, Y ^{[1
]}

Imoto, Y ^{[1
]}

Tano, Y ^{[1
]}

机构：

[1] Osaka Univ, Sch Med E7, Dept Ophthalmol, Suita, Osaka 5650871, Japan

来源：

AMERICAN JOURNAL OF OPHTHALMOLOGY | 2002年 / 134卷 / 03期

关键词：

D O I：

10.1016/S0002-9394(02)01575-1

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE: To evaluate the rapid effects of pulse corti, costeroid therapy on the serous retinal detachment found at the acute phase of Vogt-Koyanagi-Harada disease. DESIGN: Interventional case series. METHODS: Nine Japanese patients determined to be at the acute phase of Vogt-Koyanagi-Harada disease with serous retinal detachment were treated with pulse corticosteroid therapy. Optical coherence tomography was used to follow the resolution of the retinal detachment. RESULTS: Optical coherence tomography images showed a marked decrease in the retinal detachment immediately after the first intravenous injection of corticosteroid. and subsequent resolution. CONCLUSION: The rapid improvement of serous retinal detachment associated with Vogt-Koyanagi-Harada disease following pulse corticosteroid therapy supports an early therapeutic mechanism related to improved permeability of capillaries and permeability of the blood-retinal barrier rather than an anti-inflammatory or immunosuppressive action. (C) 2002 by Elsevier Science Inc. All rights reserved.

引用

页码：454 / 456

页数：3

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