APOE genotype effects on Alzheimer's disease onset and epidemiology

被引：190

作者：

Ashford, JW ^{[1
]}

机构：

[1] Stanford VA Alzheimer Ctr, Palo Alto, CA 94304 USA

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2004年 / 23卷 / 03期

关键词：

Alzheimer's disease; dementia; genetics; apolipoprotein E; Gompertz; aging; epidemiology;

D O I：

10.1385/JMN:23:3:157

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The risk of developing Alzheimer's disease (AD) is tied most closely to age and appears to follow Gompertzian kinetics. However, specific genetic factors are also linked closely to AD, and the apolipoprotein E (APOE) genotype accounts for as much of 50% of the attributable risk for AD in many populations. This paper reviews the onset, diagnosis, and epidemiology of AD, specifically with regard to the APOE genotype and the interaction of the genotype with age.

引用

页码：157 / 165

页数：9

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