Synthetic MRI in the Detection of Multiple Sclerosis Plaques

被引：124

作者：

Hagiwara, A. ^{[1
,3
]}

Hori, M. ^{[1
]}

Yokoyama, K. ^{[2
]}

Takemura, M. Y. ^{[1
]}

Andica, C. ^{[1
]}

Tabata, T. ^{[1
]}

Kamagata, K. ^{[1
]}

Suzuki, M. ^{[1
]}

Kumamaru, K. K. ^{[1
]}

Nakazawa, M. ^{[1
,4
]}

Takano, N. ^{[1
]}

Kawasaki, H. ^{[1
]}

Hamasaki, N. ^{[1
]}

Kunimatsu, A. ^{[3
]}

Aoki, S. ^{[1
]}

机构：

[1] Juntendo Univ, Sch Med, Dept Radiol, Tokyo, Japan

[2] Juntendo Univ, Sch Med, Dept Neurol, Tokyo, Japan

[3] Univ Tokyo, Grad Sch Med, Dept Radiol, Tokyo, Japan

[4] Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Radiol Sci, Tokyo, Japan

来源：

AMERICAN JOURNAL OF NEURORADIOLOGY | 2017年 / 38卷 / 02期

基金：

日本学术振兴会;

关键词：

SENSITIVE INVERSION-RECOVERY; INTRACORTICAL LESIONS; DIAGNOSTIC-CRITERIA; IMAGE SYNTHESIS; PULSE SEQUENCE; WHITE-MATTER; BRAIN; GUIDELINES; CONTRAST; OPTIMIZATION;

D O I：

10.3174/ajnr.A5012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

In this retrospective study, synthetic T2-weighted, FLAIR, double inversion recovery, and phase-sensitive inversion recovery images were produced in 12 patients with MS after quantification of T1 and T2 values and proton density. Double inversion recovery images were optimized for each patient by adjusting the TI. The number of visible plaques was determined by a radiologist for a set of these 4 types of synthetic MR images and a set of conventional T1-weighted inversion recovery, T2-weighted, and FLAIR images. Conventional 3D double inversion recovery and other available images were used as the criterion standard. Synthetic MR imaging enabled detection of more MS plaques than conventional MR imaging in a comparable acquisition time (approximately 7 minutes). The contrast for MS plaques on synthetic double inversion recovery images was better than on conventional double inversion recovery images. BACKGROUND AND PURPOSE: Synthetic MR imaging enables the creation of various contrast-weighted images including double inversion recovery and phase-sensitive inversion recovery from a single MR imaging quantification scan. Here, we assessed whether synthetic MR imaging is suitable for detecting MS plaques. MATERIALS AND METHODS: Quantitative and conventional MR imaging data on 12 patients with MS were retrospectively analyzed. Synthetic T2-weighted, FLAIR, double inversion recovery, and phase-sensitive inversion recovery images were produced after quantification of T1 and T2 values and proton density. Double inversion recovery images were optimized for each patient by adjusting the TI. The number of visible plaques was determined by a radiologist for a set of these 4 types of synthetic MR images and a set of conventional T1-weighted inversion recovery, T2-weighted, and FLAIR images. Conventional 3D double inversion recovery and other available images were used as the criterion standard. The total acquisition time of synthetic MR imaging was 7 minutes 12 seconds and that of conventional MR imaging was 6 minutes 29 seconds The lesion-to-WM contrast and lesion-to-WM contrast-to-noise ratio were calculated and compared between synthetic and conventional double inversion recovery images. RESULTS: The total plaques detected by synthetic and conventional MR images were 157 and 139, respectively (P = .014). The lesion-to-WM contrast and contrast-to-noise ratio on synthetic double inversion recovery images were superior to those on conventional double inversion recovery images (P = .001 and < 0.001, respectively). CONCLUSIONS: Synthetic MR imaging enabled detection of more MS plaques than conventional MR imaging in a comparable acquisition time. The contrast for MS plaques on synthetic double inversion recovery images was better than on conventional double inversion recovery images.

引用

页码：257 / 263

页数：7

共 28 条

[1]

The Advantage of Synthetic MRI for the Visualization of Early White Matter Change in an Infant with Sturge-Weber Syndrome [J].