A novel human Mcm protein: Homology to the yeast replication protein Mis5 and chromosomal location

被引：19

作者：

Holthoff, HP

Hameister, H

Knippers, R

机构：

[1] UNIV KONSTANZ,DIV BIOL,D-78434 CONSTANCE,GERMANY

[2] UNIV ULM,D-89069 ULM,GERMANY

来源：

GENOMICS | 1996年 / 37卷 / 01期

关键词：

D O I：

10.1006/geno.1996.0530

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mcm proteins perform functions related to the regulation of eukaryotic genome replication, Previous work has shown that human cells contain at least five different Mcm proteins. We report now the amino acid sequence of an additional human Mcm protein, p105Mcm, and show that it is homologous to the Schizosaccharomyces pombe protein Mis5. We demonstrate that the gene for protein p105Mcm (HGMW-approved symbol, MCM6) is located on human chromosome 2q14-q21. All six known human Mcm proteins have now been sequenced and compared to their yeast counterparts. (C) 1996 Academic Press, Inc.

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页码：131 / 134

页数：4

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