A basic science view of acute kidney injury biomarkers

被引：213

作者：

Charlton, Jennifer R. ^{[1
,2
]}

Portilla, Didier ^{[3
]}

Okusa, Mark D. ^{[2
,4
]}

机构：

[1] Univ Virginia Hlth Syst, Dept Pediat, Charlottesville, VA USA

[2] Univ Virginia Hlth Syst, Div Nephrol, Charlottesville, VA 22903 USA

[3] Univ Arkansas Med Sci, Dept Med, Little Rock, AR 72205 USA

[4] Univ Virginia Hlth Syst, Dept Med, Charlottesville, VA USA

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2014年 / 29卷 / 07期

关键词：

acute renal failure; cystatin-C; IL-18; KIM-1; NGAL; GELATINASE-ASSOCIATED LIPOCALIN; ACID-BINDING PROTEIN; SERUM CYSTATIN-C; EARLY URINARY BIOMARKER; BETA-D-GLUCOSAMINIDASE; GAMMA-INDUCING FACTOR; ACUTE RENAL INJURY; FROZEN STORAGE; CASPASE-1-DEFICIENT MICE; PROXIMAL TUBULES;

D O I：

10.1093/ndt/gft510

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Over the last decade, significant progress has been made in the identification and validation of novel biomarkers as well as refinements in the use of serum creatinine as a marker of kidney function. These advances have taken advantage of laboratory investigations, which have identified these novel molecules that serve important biological functions in the pathogenesis of acute kidney injury (AKI). As we advance and validate these markers for clinical studies in AKI, we recognize that they serve not only to improve our understanding of AKI, but they could also serve as potential targets for the treatment of AKI. This review will underscore the biological basis of specific biomarkers that will contribute to the advancement in the treatment and outcomes of AKI.

引用

页码：1301 / 1311

页数：11

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