Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection

被引：35

作者：

Akula, SM ^{[1
]}

Ford, PW ^{[1
]}

Whitman, AG ^{[1
]}

Hamden, KE ^{[1
]}

Shelton, JG ^{[1
]}

McCubrey, JA ^{[1
]}

机构：

[1] E Carolina Univ, Brody Sch Med, Dept Microbiol & Immunol, Greenville, NC 27858 USA

来源：

ONCOGENE | 2004年 / 23卷 / 30期

关键词：

HHV-8; KSHV; Raf; VEGF; HB-EGF;

D O I：

10.1038/sj.onc.1207643

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human herpesvirus-8 (HHV-8/KSHV) is etiologically associated with Kaposi's sarcoma (KS) and other tumors. Constitutive activation of the mitogen-activated protein kinase ( MAPK) signaling pathway has been associated with a variety of tumors, including AIDS-related KS. The oncoprotein Raf is situated at a pivotal position in regulating the MAPK pathway. Hence, we analysed the effect of oncoprotein Raf on HHV-8 infectious entry into target cells. Here we report Raf expression to significantly enhance HHV-8 infection of target cells. These findings implicate a role for Raf not only in the infectious entry of HHV-8 but also in modulating KS pathogenesis.

引用

页码：5227 / 5241

页数：15

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