When pain after surgery doesn't go away ...

被引：35

作者：

Burke, Siun ^{[1
,2
]}

Shorten, George D. ^{[1
,2
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, Cork, Ireland

[2] Cork Univ Hosp, Dept Anaesthesia & Intens Care Med, Cork, Ireland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2009年 / 37卷

关键词：

ion channel; neural blockade; neuroplasticity; noradrenaline; pain; surgery; POSTOPERATIVE PAIN; NEUROPATHIC PAIN; BREAST SURGERY; CENTRAL SENSITIZATION; POSTSURGICAL PAIN; INFLAMMATORY PAIN; HYPERALGESIA; GABAPENTIN; PREVENTION; ANALGESIA;

D O I：

10.1042/BST0370318

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic post-surgical pain is a common, under-recognized and important clinical problem which affects millions of patients worldwide. it results from a series of neuroplastic changes associated most commonly with peripheral nerve injury at the time of surgery. Predisposing factors include the type of surgery, preoperative and acute post-operative pain intensity, and probably psychological (e.g. pain-catastrophizing) and genetic factors [e.g. GCH1 (GTP cyclohydrolase 1) haplotype]. Preventive measures which are currently available include selection of a minimally invasive surgical technique and an aggressive multimodal perioperative analgesic regimen. Very promising therapeutic agents which target the sensitization process are currently in development.

引用

页码：318 / 322

页数：5

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