The ESAT-6/WXG100 superfamily - and a new Gram-positive secretion system?

被引：280

作者：

Pallen, MJ ^{[1
]}

机构：

[1] Univ Birmingham, Med Sch, Div Immun & Infect, Birmingham B15 2TT, W Midlands, England

来源：

TRENDS IN MICROBIOLOGY | 2002年 / 10卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0966-842X(02)02345-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ESAT-6 is a small secreted protein of unknown function from Mycobacterium tuberculosis that is of fundamental importance in virulence and protective immunity. A PSI-BLAST search has identified distant homologues of ESAT-6 in more tractable bacteria, including Bacillus subtilis, Bacillus anthracis, Staphylococcus aureus and Clostridium acetobutylicum. The genes for ESAT-6-like proteins often cluster with genes encoding homologues of B. subtilis YukA. I speculate that the ESAT-6-like and YukA-like proteins form a novel Gram-positive secretion system potentially driven by the FtsK/SpoIIIE ATPase domains in the YukA-like proteins. The way is now open to investigate this hypothesis in organisms that are easier to manipulate than pathogenic mycobacteria.

引用

页码：209 / 212

页数：4

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