Biosynthesis of isoprenoids in Escherichia coli:: Stereochemistry of the reaction catalyzed by farnesyl diphosphate synthase

被引：20

作者：

Leyes, AE ^{[1
]}

Baker, JA ^{[1
]}

Poulter, CD ^{[1
]}

机构：

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 07期

关键词：

D O I：

10.1021/ol990876e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Farnesyl diphosphate (FPP) synthase from Escherichia coli catalyzes the condensation of isopentenyl diphosphate (IPP) and geranyl diphosphate (GPP) with selective removal of the pro-R hydrogen at C2 of IPP, the same stereochemistry observed for the pig liver, yeast, and avian enzymes.

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页码：1071 / 1073

页数：3

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