Reaction of N-monosubstituted hydrazones with nitroolefins:: A novel regioselective pyrazole synthesis

被引：171

作者：

Deng, Xiaohu ^{[1
]}

Mani, Neelakandha S. ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut R&D LLC, San Diego, CA 92121 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 16期

关键词：

D O I：

10.1021/ol061226v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel regioselective synthesis of substituted pyrazoles from N-monosubstituted hydrazones and nitroolefins is described. The reaction is performed in a one-pot manner and the yields range from moderate to excellent. A key nitropyrazolidine intermediate is characterized and a plausible mechanism is proposed.

引用

页码：3505 / 3508

页数：4

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