A novel one-pot method for the preparation of pyrazoles by 1,3-dipolar cycloadditions of diazo compounds generated in situ

被引：278

作者：

Aggarwal, VK

de Vicente, J

Bonnert, RV

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 ITS, Avon, England

[2] AstraZeneca R&D Charnwood, Med Chem, Loughborough LE11 5RH, Leics, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 13期

关键词：

D O I：

10.1021/jo0268409

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient one-pot procedure for the preparation of pyrazoles by 1,3-dipolar cycloaddition of diazo compounds generated in situ has been developed. Diazo compounds derived from aldehydes were reacted with terminal alkynes to furnish regioselectively 3,5-disubstituted pyrazoles. Furthermore, the reaction of N-vinylimidazole and diazo compounds derived from aldehydes gave exclusively 3-substituted pyrazoles in a one-pot process.

引用

页码：5381 / 5383

页数：3

共 18 条

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