Diversity of Human Milk Oligosaccharides and Effects on Early Life Immune Development

被引：121

作者：

Ayechu-Muruzabal, Veronica ^{[1
]}

van Stigt, Arthur H. ^{[2
]}

Mank, Marko ^{[3
,4
]}

Willemsen, Linette E. M. ^{[1
]}

Stahl, Bernd ^{[3
,4
]}

Garssen, Johan ^{[1
,3
,4
]}

van't Land, Belinda ^{[2
,3
,4
]}

机构：

[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Div Pharmacol, Fac Sci, Utrecht, Netherlands

[2] Univ Med Ctr, Wilhelmina Childrens Hosp, Lab Translat Immunol, Pediat Immunol, Utrecht, Netherlands

[3] Danone Nutricia Res, Dept Immunol, Utrecht, Netherlands

[4] Danone Nutricia Res, Dept Human Milk Res & Analyt Sci, Utrecht, Netherlands

来源：

FRONTIERS IN PEDIATRICS | 2018年 / 6卷

关键词：

human milk oligosaccharides; mucosal immunity; tolerogenic dendritic cells; infections; early life nutrition; BREAST-FED INFANTS; GROUP-B STREPTOCOCCUS; 1ST; 6; MONTHS; IN-VITRO; FUCOSYLATED OLIGOSACCHARIDES; ATOPIC-DERMATITIS; DC-SIGN; GROWTH; FORMULA; GLYCANS;

D O I：

10.3389/fped.2018.00239

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

One of the well-known features of human milk, is the capacity to protect against the risk and impact of neonatal infections, as well as to influence the onset of allergic and metabolic disease manifestations. The major objective of this review is to provide a detailed overview regarding the role of human milk, more specifically the diversity in human milk oligosaccharides (HMOS), on early life immune development. Novel insights in immune modulatory effects of HMOS obtained by in vitro as well as in vivo studies, adds to the understanding on how early life nutrition may impact immune development. Extensive description and analysis of single HMOS contributing to the diversity within the composition provided during breastfeeding will be discussed with specific emphasis on immune development and the susceptibility to neonatal and childhood infections.

引用

页数：9

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