Pattern formation via small RNA mobility

被引：300

作者：

Chitwood, Daniel H. ^{[1
,2
]}

Nogueira, Fabio T. S. ^{[1
]}

Howell, Miya D. ^{[3
,4
]}

Montgomery, Taiowa A. ^{[4
,5
]}

Carrington, James C. ^{[3
,4
,5
]}

Timmermans, Marja C. P. ^{[1
,2
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[2] Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA

[3] Oregon State Univ, Ctr Genome Res & Biocomp, Corvallis, OR 97331 USA

[4] Oregon State Univ, Dept Bot & Plant Pathol, Corvallis, OR 97331 USA

[5] Oregon State Univ, Mol & Cellular Biol Program, Corvallis, OR 97331 USA

来源：

GENES & DEVELOPMENT | 2009年 / 23卷 / 05期

关键词：

Small RNA; miRNA; Arabidopsis; leaf; polarity; pattern fomation; TRANS-ACTING SIRNAS; EMBRYONIC-DEVELOPMENT; MEDIATED REPRESSION; LEAF POLARITY; ARABIDOPSIS; BIOGENESIS; MICRORNAS; EXPRESSION; TARGETS; PLANTS;

D O I：

10.1101/gad.1770009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs and trans-acting siRNAs (ta-siRNAs) have important regulatory roles in development. Unlike other developmentally important regulatory molecules, small RNAs are not known to act as mobile signals during development. Here, we show that low-abundant, conserved ta-siRNAs, termed tasiR-ARFs, move intercellularly from their defined source of biogenesis on the upper (adaxial) side of leaves to the lower (abaxial) side to create a gradient of small RNAs that patterns the abaxial determinant AUXIN RESPONSE FACTOR3. Our observations have important ramifications for the function of small RNAs and suggest they can serve as mobile, instructive signals during development.

引用

页码：549 / 554

页数：6

共 28 条

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