Mechanisms of drug combinations: interaction and network perspectives

被引：742

作者：

Jia, Jia ^{[1
]}

Zhu, Feng ^{[1
]}

Ma, Xiaohua ^{[1
,2
]}

Cao, Zhiwei W. ^{[2
]}

Li, Yixue X. ^{[2
]}

Chen, Yu Zong ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Bioinformat & Drug Design Grp, Dept Pharm, Dept Biol Sci,Ctr Computat Sci & Engn, Singapore 117543, Singapore

[2] Shanghai Ctr Bioinformat Technol, Shanghai 201203, Peoples R China

来源：

NATURE REVIEWS DRUG DISCOVERY | 2009年 / 8卷 / 02期

基金：

中国国家自然科学基金;

关键词：

TYROSINE KINASE INHIBITOR; GROWTH-FACTOR RECEPTOR; HIV-1; REVERSE-TRANSCRIPTASE; SENSITIVE K+ CHANNELS; ATYPICAL RETINOID ST1926; BETA-LACTAM ANTIBIOTICS; TAXOL-INDUCED APOPTOSIS; DNA TOPOISOMERASE-I; BREAST-CANCER; CELL-LINES;

D O I：

10.1038/nrd2683

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Understanding the molecular mechanisms underlying synergistic, potentiative and antagonistic effects of drug combinations could facilitate the discovery of novel efficacious combinations and multi-targeted agents. In this article, we describe an extensive investigation of the published literature on drug combinations for which the combination effect has been evaluated by rigorous analysis methods and for which relevant molecular interaction profiles of the drugs involved are available. Analysis of the 117 drug combinations identified reveals general and specific modes of action, and highlights the potential value of molecular interaction profiles in the discovery of novel multicomponent therapies.

引用

页码：111 / 128

页数：18

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