TNF-related apoptosis-inducing ligand level in Alzheimer's disease

被引：26

作者：

Genc, Sermin ^{[1
]}

Egrilmez, Mehtap Yuksel ^{[1
]}

Yaka, Erdem ^{[2
]}

Cavdar, Zahide ^{[1
]}

Iyilikci, Leyla ^{[3
]}

Yener, Gorsev ^{[2
]}

Genc, Kursad ^{[4
]}

机构：

[1] Dokuz Eylul Univ, Sch Med, Learning Resources Ctr, Res Lab, TR-35340 Izmir, Turkey

[2] Dokuz Eylul Univ, Sch Med, Dept Neurol, TR-35340 Izmir, Turkey

[3] Dokuz Eylul Univ, Sch Med, Dept Anesthesiol & Reanimat, TR-35340 Izmir, Turkey

[4] Dokuz Eylul Univ, Hlth & Sci Inst, TR-35340 Izmir, Turkey

来源：

NEUROLOGICAL SCIENCES | 2009年 / 30卷 / 03期

关键词：

Alzheimer's disease; TRAIL; Brain; Neurodegeneration; Microglia; Neuron; INTERFERON-GAMMA; HUMAN BRAIN; EXPRESSION; TRAIL; ASTROCYTES; RECEPTORS; DIAGNOSIS;

D O I：

10.1007/s10072-009-0047-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

In the present study, we determined the significance of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in Alzheimer's disease (AD). We characterized the expression of TRAIL protein in the cerebrospinal fluid (CSF) and serum with ELISA and TRAIL mRNA in the peripheral blood mononuclear cells (PBMCs) with real-time PCR in 22 patients with AD and 20 control cases. We could not find TRAIL protein in the CSF samples. The concentration of TRAIL protein in sera from patients with AD was not different from controls. However, there was an inverse correlation between serum TRAIL levels and Mini-Mental State Examination scores in AD patients. Also we did not find significant difference in TRAIL mRNA in the PBMCs of patients with AD when compared with control group. Our data indicate that TRAIL serum level decreases in the late stage of disease.

引用

页码：263 / 267

页数：5

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