Induction of CD44 expression in stab wounds of the brain: long term persistence of CD44 expression

被引:16
作者
Stylli, SS
Kaye, AH
Novak, U [1 ]
机构
[1] Univ Melbourne, Royal Melbourne Hosp, Dept Surg, Parkville, Vic 3050, Australia
[2] Univ Melbourne, Royal Melbourne Hosp, Dept Neurosurg, Parkville, Vic 3050, Australia
关键词
D O I
10.1054/jocn.1999.0187
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We studied the expression of the hyaluronan receptor protein CD44 in the mouse brain in response to stab injuries. CD44 expression was strongly activated in the area surrounding the injury within 2 days and then persisted for over 2 months. The expression extended in a direct line the depth of the actual wound inflicted. It appears that CD44 may be involved in the wound healing processes following injury to the brain.
引用
收藏
页码:137 / 140
页数:4
相关论文
共 26 条
[1]   CD44 IS THE PRINCIPAL CELL-SURFACE RECEPTOR FOR HYALURONATE [J].
ARUFFO, A ;
STAMENKOVIC, I ;
MELNICK, M ;
UNDERHILL, CB ;
SEED, B .
CELL, 1990, 61 (07) :1303-1313
[2]   HYALURONAN AND HYALURONECTIN IN THE EXTRACELLULAR-MATRIX OF HUMAN BRAIN-TUMOR STROMA [J].
DELPECH, B ;
MAINGONNAT, C ;
GIRARD, N ;
CHAUZY, C ;
MAUNOURY, R ;
OLIVIER, A ;
TAYOT, J ;
CREISSARD, P .
EUROPEAN JOURNAL OF CANCER, 1993, 29A (07) :1012-1017
[3]   Regulation of CD44 gene expression by the proinflammatory cytokine interleukin-1β in vascular smooth muscle cells [J].
Foster, LC ;
Arkonac, BM ;
Sibinga, NES ;
Shi, CW ;
Perrella, MA ;
Haber, E .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (32) :20341-20346
[4]  
Ghirnikar RS, 1996, J NEUROSCI RES, V46, P727
[5]  
Jaworski DM, 1996, CANCER RES, V56, P2293
[6]   BEHAB, A NEW MEMBER OF THE PROTEOGLYCAN TANDEM REPEAT FAMILY OF HYALURONAN-BINDING PROTEINS THAT IS RESTRICTED TO THE BRAIN [J].
JAWORSKI, DM ;
KELLY, GM ;
HOCKFIELD, S .
JOURNAL OF CELL BIOLOGY, 1994, 125 (02) :495-509
[7]   HYALURONIC-ACID CD44H INTERACTION INDUCES CELL DETACHMENT AND STIMULATES MIGRATION AND INVASION OF HUMAN GLIOMA-CELLS IN-VITRO [J].
KOOCHEKPOUR, S ;
PILKINGTON, GJ ;
MERZAK, A .
INTERNATIONAL JOURNAL OF CANCER, 1995, 63 (03) :450-454
[8]   VEGF mRNA and its receptor flt-1 are expressed in reactive astrocytes following neural grafting and tumor cell implantation in the adult CNS [J].
Krum, JM ;
Rosenstein, JM .
EXPERIMENTAL NEUROLOGY, 1998, 154 (01) :57-65
[9]   DIFFERENTIAL EXPRESSION OF THE CD44 MOLECULE IN HUMAN BRAIN-TUMORS [J].
KUPPNER, MC ;
VAN MEIR, E ;
GAUTHIER, T ;
HAMOU, MF ;
DETRIBOLET, N .
INTERNATIONAL JOURNAL OF CANCER, 1992, 50 (04) :572-577
[10]   ENHANCED EXPRESSION OF THE DEVELOPMENTALLY REGULATED EXTRACELLULAR-MATRIX MOLECULE TENASCIN FOLLOWING ADULT BRAIN INJURY [J].
LAYWELL, ED ;
DORRIES, U ;
BARTSCH, U ;
FAISSNER, A ;
SCHACHNER, M ;
STEINDLER, DA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :2634-2638