One-Pot Double Suzuki-Miyaura Couplings: Rapid Access to Nonsymmetrical Tri(hetero)aryl Derivatives

被引：49

作者：

Beaumard, Floriane ^{[1
]}

Dauban, Philippe ^{[1
]}

Dodd, Robert H. ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, UPR 2301, F-91198 Gif Sur Yvette, France

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 08期

关键词：

PYRROLE; ANNULATION; PHASE; ACIDS;

D O I：

10.1021/ol900358n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe a one-pot, simultaneous Suzuki-Miyaura cross-coupling of two different aryl boronic acids with symmetrical dibromo aryl and heterocyclic substrates to give as major products the unsymmetrical disubstituted tri(hetero)aryl derivatives. Yields of unsymmetrical dicoupled products were generally in the 52-75% range. This methodology is particularly suited to the generation of chemical libraries, as well as to the synthesis of biologically active or natural product analogs.

引用

页码：1801 / 1804

页数：4

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