Synthesis of (-)-laulimalide: an agent for microtubule stabilization

被引：52

作者：

Williams, DR ^{[1
]}

Mi, L ^{[1
]}

Mullins, RJ ^{[1
]}

Stites, RE ^{[1
]}

机构：

[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 27期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(02)00907-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective synthesis or (-)-laulimalide is described. Key reactions include a convergent allylation coupling reaction, asymmetric conjugate addition, the allenylstannane Ferrier reaction and a chelation-controlled alkenylzine addition as the basis for stereocontrol in critical elements of chirality. (C) 20021 Elsevier Science Ltd. All rights reserved.

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页码：4841 / 4844

页数：4

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