Prognostic Indicators for Ebola Patient Survival

被引：50

作者：

Crowe, Samuel J. ^{[1
]}

Maenner, Matthew J. ^{[1
,7
]}

Kuah, Solomon ^{[2
]}

Erickson, Bobbie Rae ^{[1
]}

Coffee, Megan ^{[2
]}

Knust, Barbara ^{[1
]}

Klena, John ^{[1
]}

Foday, Joyce ^{[3
]}

Hertz, Darren ^{[2
]}

Hermans, Veerle ^{[4
]}

Achar, Jay ^{[5
]}

Caleo, Grazia M. ^{[5
]}

Van Herp, Michel ^{[4
]}

Albarino, Cesar G. ^{[1
]}

Amman, Brian ^{[1
]}

Basile, Alison Jane ^{[6
]}

Bearden, Scott ^{[6
]}

Belser, Jessica A. ^{[1
]}

Bergeron, Eric ^{[1
]}

Blau, Dianna ^{[1
]}

Brault, Aaron C. ^{[6
]}

Campbell, Shelley ^{[1
]}

Flint, Mike ^{[1
]}

Gibbons, Aridth ^{[1
]}

Goodman, Christin ^{[6
]}

McMullan, Laura ^{[1
]}

Paddock, Christopher ^{[1
]}

Russell, Brandy ^{[6
]}

Selzer, Johanna S. ^{[1
]}

Sanchez, Angela ^{[1
]}

Sealy, Tara ^{[1
]}

Wang, David ^{[1
]}

Saffa, Gbessay ^{[3
]}

Turay, Alhajie ^{[3
]}

Nichol, Stuart T. ^{[1
]}

Towner, Jonathan S. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop A38, Atlanta, GA 30329 USA

[2] Int Rescue Comm, New York, NY USA

[3] Minist Hlth & Sanitat, Bo Town, Sierra Leone

[4] Medecins Sans Frontieres, Brussels, Belgium

[5] Medecins Sans Frontieres, London, England

[6] Ctr Dis Control & Prevent, Ft Collins, CO USA

[7] Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop E86, Atlanta, GA 30329 USA

来源：

EMERGING INFECTIOUS DISEASES | 2016年 / 22卷 / 02期

关键词：

VIRUS-DISEASE; HEMORRHAGIC-FEVER; SIERRA-LEONE; WEST-AFRICA; VIRAL LOAD; MANAGEMENT; TRANSMISSION; FEATURES; OUTCOMES; SUDAN;

D O I：

10.3201/eid2202.151250

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission and quantitative real-time reverse transcription PCR cycle threshold (C-t), a surrogate for viral load, in first Ebola virus positive blood sample tested. Of these patients, 151 were alive when detected and had reported healthcare facility admission dates and Ct values available. Time from symptom onset to healthcare facility admission was not associated with survival, but viral load in the first Ebola virus-positive blood sample was inversely associated with survival: 52 (87%) of 60 patients with a C-t of >= 24 survived and 20 (22%) of 91 with a C-t of <24 survived. C-t values may be useful for clinicians making treatment decisions or managing patient or family expectations.

引用

页码：217 / 223

页数：7

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