Hyperosmolar Sodium Chloride, p38 Mitogen Activated Protein and Cytokine-Mediated Inflammation

Although there is increasing clinical evidence that high salt intake contributes to cardiovascular events and deaths seemingly independent of hypertension, the molecular mechanism for increased atherogenesis remains unclear. Vessel wall inflammation secondary to proinflammatory cytokines is one mechanism for atherogenesis. The role of mitogen activated protein kinase (MAPK) p38 in cytokine production such as IL-1, TNF-alpha, and IL-8 are well established. The link between inflammation and salt intake likely includes p38 MAPK as hyperosmolar sodium chloride triggers phosphorylation of p38 MAPK and stimulates gene expression and synthesis of proinflammatory cytokines. Hence a possible link of high salt intake, inflammation, and atherogenesis may be one molecular mechanism for the association of high salt intake and cardiovascular events.