Biologic functions and signaling of the interleukin-4 receptor complexes

被引：37

作者：

Gessner, A ^{[1
]}

Röllinghoff, M ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Inst Clin Microbiol Immunol & Hyg, D-91054 Erlangen, Germany

来源：

IMMUNOBIOLOGY | 2000年 / 201卷 / 3-4期

关键词：

D O I：

10.1016/S0171-2985(00)80084-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-4 is a pleiotropic cytokine which plays a pivotal role in shaping immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. This review will summarize the current knowledge on the molecular structure of the different types of IL-4 receptor (IL-4R) complexes as well as the signal transduction mechanisms induced by IL-4 leading to cellular proliferation and / or gene activation. IL-4 effects are modulated by soluble forms of the respective receptor molecules which are produced by several immune cells in a regulated manner. The biological impact of recently described IL-4R allotypes of mice and humans as well as the results of studies with IL-4R knockout mice will be particularly emphasized.

引用

页码：285 / 307

页数：23

共 145 条

[1] Functional diversity of helper T lymphocytes [J].

Abbas, AK ;

Murphy, KM ;

Sher, A .

NATURE, 1996, 383 (6603) :787-793

[2] Mouse macrophage development in the absence of the common gamma chain: Defining receptor complexes responsible for IL-4 and IL-13 signaling [J].

Andersson, A ;

Grunewald, SM ;

Duschl, A ;

Fischer, A ;

DiSanto, JP .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (07) :1762-1768

[3] AN INTERLEUKIN-4 (IL-4) MUTANT PROTEIN INHIBITS BOTH IL-4 OR IL-13-INDUCED HUMAN IMMUNOGLOBULIN-G4 (IGG4) AND IGE SYNTHESIS AND B-CELL PROLIFERATION - SUPPORT FOR A COMMON COMPONENT SHARED BY IL-4 AND IL-13 RECEPTORS [J].

AVERSA, G ;

PUNNONEN, J ;

COCKS, BG ;

MALEFYT, RD ;

VEGA, F ;

ZURAWSKI, SM ;

ZURAWSKI, G ;

DEVRIES, JE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) :2213-2218

[4]

Blum H, 1996, J IMMUNOL, V157, P1846

[5] MODULATION OF MACROPHAGE FUNCTION BY TRANSFORMING GROWTH-FACTOR-BETA, INTERLEUKIN-4, AND INTERLEUKIN-10 [J].

BOGDAN, C ;

NATHAN, C .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1993, 685 :713-739

[6]

BROWN KD, 1989, J IMMUNOL, V142, P679

[7] DEFECTIVE LYMPHOID DEVELOPMENT IN MICE LACKING EXPRESSION OF THE COMMON CYTOKINE RECEPTOR-GAMMA CHAIN [J].

CAO, XQ ;

SHORES, EW ;

HULI, J ;

ANVER, MR ;

KELSALL, BL ;

RUSSELL, SM ;

DRAGO, J ;

NOGUCHI, M ;

GRINBERG, A ;

BLOOM, ET ;

PAUL, WE ;

KATZ, SI ;

LOVE, PE ;

LEONARD, WJ .

IMMUNITY, 1995, 2 (03) :223-238

[8] Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain [J].

Caput, D ;

Laurent, P ;

Kaghad, M ;

Lelias, JM ;

Lefort, S ;

Vita, N ;

Ferrara, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (28) :16921-16926

[9]

Castro A, 1999, J IMMUNOL, V162, P1261

[10] Jak1 expression is required for mediating interleukin-4 induced tyrosine phosphorylation of insulin receptor substrate and state signaling molecules [J].

Chen, XH ;

Patel, BKR ;

Wang, LM ;

Frankel, M ;

Ellmore, N ;

Flavell, RA ;

LaRochelle, WJ ;

Pierce, JH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) :6556-6560

← 1 2 3 4 5 6 7 8 9 10 →