Biologic functions and signaling of the interleukin-4 receptor complexes

被引：37

作者：

Gessner, A ^{[1
]}

Röllinghoff, M ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Inst Clin Microbiol Immunol & Hyg, D-91054 Erlangen, Germany

来源：

IMMUNOBIOLOGY | 2000年 / 201卷 / 3-4期

关键词：

D O I：

10.1016/S0171-2985(00)80084-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-4 is a pleiotropic cytokine which plays a pivotal role in shaping immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. This review will summarize the current knowledge on the molecular structure of the different types of IL-4 receptor (IL-4R) complexes as well as the signal transduction mechanisms induced by IL-4 leading to cellular proliferation and / or gene activation. IL-4 effects are modulated by soluble forms of the respective receptor molecules which are produced by several immune cells in a regulated manner. The biological impact of recently described IL-4R allotypes of mice and humans as well as the results of studies with IL-4R knockout mice will be particularly emphasized.

引用

页码：285 / 307

页数：23

共 145 条

[81] X-SCID B cell responses to interleukin-4 and interleukin-13 are mediated by a receptor complex that includes the interleukin-4 receptor alpha chain (p140) but not the gamma c chain [J].

Matthews, DJ ;

Hibbert, L ;

Friedrich, K ;

Minty, A ;

Callard, RE .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (01) :116-121

[82] FUNCTION OF THE INTERLEUKIN-2 (IL-2) RECEPTOR GAMMA-CHAIN IN BIOLOGIC RESPONSES OF X-LINKED SEVERE COMBINED IMMUNODEFICIENT B-CELLS TO IL-2, IL-4, IL-13, AND IL-15 [J].

MATTHEWS, DJ ;

CLARK, PA ;

HERBERT, J ;

MORGAN, G ;

ARMITAGE, RJ ;

KINNON, C ;

MINTY, A ;

GRABSTEIN, KH ;

CAPUT, D ;

FERRARA, P ;

CALLARD, R .

BLOOD, 1995, 85 (01) :38-42

[83] Cloning of the human IL-13R alpha 1 chain and reconstitution with the IL-4R alpha of a functional IL-4/IL-13 receptor complex [J].

Miloux, B ;

Laurent, P ;

Bonnin, O ;

Lupker, J ;

Caput, D ;

Vita, N ;

Ferrara, P .

FEBS LETTERS, 1997, 401 (2-3) :163-166

[84]

Minshall C, 1999, J IMMUNOL, V162, P4542

[85] Ile50Val variant of IL4Rα upregulates IgE synthesis and associates with atopic asthma [J].

Mitsuyasu, H ;

Izuhara, K ;

Mao, XQ ;

Gao, PS ;

Arinobu, Y ;

Enomoto, T ;

Kawai, M ;

Sasaki, S ;

Dake, Y ;

Hamasaki, N ;

Shirakawa, T ;

Hopkin, JM .

NATURE GENETICS, 1998, 19 (02) :119-120

[86]

Mitsuyasu H, 1999, J IMMUNOL, V162, P1227

[87] Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway [J].

Miyazaki, T ;

Takaoka, A ;

Nogueira, L ;

Dikic, I ;

Fujii, H ;

Tsujino, S ;

Mitani, Y ;

Maeda, M ;

Schlessinger, J ;

Taniguchi, T .

GENES & DEVELOPMENT, 1998, 12 (06) :770-775

[88]

Mohrs M, 1999, J IMMUNOL, V162, P7302

[89] THE MURINE INTERLEUKIN-4 RECEPTOR - MOLECULAR-CLONING AND CHARACTERIZATION OF SECRETED AND MEMBRANE-BOUND FORMS [J].

MOSLEY, B ;

BECKMANN, MP ;

MARCH, CJ ;

IDZERDA, RL ;

GIMPEL, SD ;

VANDENBOS, T ;

FRIEND, D ;

ALPERT, A ;

ANDERSON, D ;

JACKSON, J ;

WIGNALL, JM ;

SMITH, C ;

GALLIS, B ;

SIMS, JE ;

URDAL, D ;

WIDMER, MB ;

COSMAN, D ;

PARK, LS .

CELL, 1989, 59 (02) :335-348

[90]

Murata T, 1998, INT J MOL MED, V1, P551

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