Ile50Val variant of IL4Rα upregulates IgE synthesis and associates with atopic asthma

被引：293

作者：

Mitsuyasu, H

Izuhara, K

Mao, XQ

Gao, PS

Arinobu, Y

Enomoto, T

Kawai, M

Sasaki, S

Dake, Y

Hamasaki, N

Shirakawa, T ^{[1
]}

Hopkin, JM

机构：

[1] Churchill Hosp, Osler Chest Unit, Oxford OX3 7LJ, England

[2] Kyushu Univ, Dept Clin Chem & Lab Med, Fac Med, Fukuoka 812, Japan

[3] Wakayama Med Ctr, Dept Otolaryngol, Japanese Red Cross Soc, Wakayama, Japan

[4] Kyoto Prevent Med Ctr, Kyoto, Japan

[5] Osaka Med Coll, Dept Pediat, Takatsuki, Osaka 569, Japan

来源：

NATURE GENETICS | 1998年 / 19卷 / 02期

关键词：

D O I：

10.1038/472

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

引用

页码：119 / 120

页数：2

共 15 条

[1] Common polymorphisms in the coding part of the IL4-receptor gene [J].

Deichmann, K ;

Bardutzky, J ;

Forster, J ;

Heinzmann, A ;

Kuehr, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 231 (03) :696-697

[2]

Deichmann KA, 1998, CLIN EXP ALLERGY, V28, P151

[3]

GARIZZI JP, 1990, INT IMMUNOL, V2, P669

[4] The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor [J].

Hershey, GKK ;

Friedrich, MF ;

Esswein, LA ;

Thomas, ML ;

Chatila, TA .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (24) :1720-1725

[5] HUMAN INTERLEUKIN-4 RECEPTOR CONFERS BIOLOGICAL RESPONSIVENESS AND DEFINES A NOVEL RECEPTOR SUPERFAMILY [J].

IDZERDA, RL ;

MARCH, CJ ;

MOSLEY, B ;

LYMAN, SD ;

VANDENBOS, T ;

GIMPEL, SD ;

DIN, WS ;

GRABSTEIN, KH ;

WIDMER, MB ;

PARK, LS ;

COSMAN, D ;

BECKMANN, MP .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (03) :861-873

[6] THE CHIMERIC RECEPTOR BETWEEN INTERLEUKIN-2 RECEPTOR-BETA CHAIN AND INTERLEUKIN-4 RECEPTOR TRANSDUCES INTERLEUKIN-2 SIGNAL [J].

IZUHARA, K ;

MIYAJIMA, A ;

HARADA, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 190 (03) :992-1000

[7] Signal transduction pathway of interleukin-4 and interleukin-13 in human B cells derived from X-linked severe combined immunodeficiency patients [J].

Izuhara, K ;

Heike, T ;

Otsuka, T ;

Yamaoka, K ;

Mayumi, M ;

Imamura, T ;

Niho, Y ;

Harada, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (02) :619-622

[8] Association between genetic variants of mast-cell chymase and eczema [J].

Mao, XQ ;

Shirakawa, T ;

Yoshikawa, T ;

Yoshikawa, K ;

Kawai, M ;

Sasaki, S ;

Enomoto, T ;

Hashimoto, T ;

Furuyama, J ;

Hopkin, JM ;

Morimoto, K .

LANCET, 1996, 348 (9027) :581-583

[9] An interleukin 4 (IL-4)-independent pathway for CD4(+) T cell IL-4 production is revealed in IL-4 receptor-deficient mice [J].

NobenTrauth, N ;

Shultz, LD ;

Brombacher, F ;

Urban, JF ;

Gu, H ;

Paul, WE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) :10838-10843

[10]

SCULTE T, 1997, J EXP MED, V186, P1419

← 1 2 →