Dendritic cells and the complexity of microbial infection

被引：62

作者：

Rescigno, M ^{[1
]}

机构：

[1] Ist Europeo Oncol, Dept Expt Oncol, I-20141 Milan, Italy

来源：

TRENDS IN MICROBIOLOGY | 2002年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0966-842X(02)02425-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dendritic cells (DCs) can discriminate between different classes of microorganisms, present antigens to T cells and initiate innate and adaptive immune responses. DCs do not act individually, and their function can be fine-tuned by environmental and tissue factors as well as by the microorganisms themselves. Recent studies have reported DCs can integrate stimuli derived from microbial pathogens and other cells present at, or recruited to, the site of infection. These interactions can determine the success or failure of the immune response induced against pathogens.

引用

页码：425 / 431

页数：7

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