Central infusion of the AT(1) receptor antagonist losartan inhibits thirst but not sodium appetite in cattle

被引:11
作者
BlairWest, JR [1 ]
Denton, DA [1 ]
McKinley, MJ [1 ]
Weisinger, RS [1 ]
机构
[1] UNIV MELBOURNE, HOWARD FLOREY INST EXPT PHYSIOL & MED, PARKVILLE, VIC 3052, AUSTRALIA
关键词
water restriction; sodium depletion; PD-123319; angiotensin III; angiotensin II receptors;
D O I
10.1152/ajpregu.1997.272.6.R1940
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Experiments in cattle compared the effects of intracerebroventricular (ICV) infusions of losartan and PD-123319 on water intake caused by water restriction, ICV infusion of hypertonic NaCl, or ICV infusion of angiotensin II (ANG II). The effects of these receptor antagonists on sodium intake caused by sodium depletion were also examined. Losartan infusion caused dose-dependent inhibition of the high water intake caused by the physiological stimulus of water restriction or by ANG II infusion but did not affect salt appetite. PD-123319 infused at equimolar or greater (in ANG II experiments) doses did not affect water intake or salt intake due to sodium depletion. The results of these ICV infusion experiments confirm our earlier proposal that the physiological regulation of water intake in cattle may be mediated by ANG II acting centrally via AT(1) receptors. The dose of losartan that inhibited thirst in cattle did not inhibit sodium appetite, nor did an equimolar dose of PD-123319.
引用
收藏
页码:R1940 / R1945
页数:6
相关论文
共 20 条
[1]   INTRACEREBROVENTRICULAR ANGIOTENSIN II-INDUCED THIRST AND SODIUM APPETITE IN RAT ARE BLOCKED BY THE AT1 RECEPTOR ANTAGONIST, LOSARTAN (DUP-753), BUT NOT BY THE AT(2) ANTAGONIST, CGP-42112B [J].
BERESFORD, MJ ;
FITZSIMONS, JT .
EXPERIMENTAL PHYSIOLOGY, 1992, 77 (05) :761-764
[2]   SODIUM APPETITE AND THIRST IN CATTLE SUBJECTED TO DEHYDRATION [J].
BLAIRWEST, JR ;
DENTON, DA ;
MCKINLEY, MJ ;
WEISINGER, RS .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (05) :R1212-R1218
[3]   ANGIOTENSIN-RELATED SODIUM APPETITE AND THIRST IN CATTLE [J].
BLAIRWEST, JR ;
DENTON, DA ;
MCKINLEY, MJ ;
WEISINGER, RS .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (02) :R205-R211
[4]   THIRST AND BRAIN ANGIOTENSIN IN CATTLE [J].
BLAIRWEST, JR ;
DENTON, DA ;
MCKINLEY, MJ ;
WEISINGER, RS .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (02) :R204-R210
[5]   THIRST INDUCED BY INCREASING BRAIN SODIUM CONCENTRATION IS MEDIATED BY BRAIN ANGIOTENSIN [J].
BLAIRWEST, JR ;
BURNS, P ;
DENTON, DA ;
FERRARO, T ;
MCBURNIE, MI ;
TARJAN, E ;
WEISINGER, RS .
BRAIN RESEARCH, 1994, 637 (1-2) :335-338
[6]   THE EFFECT OF THE PUTATIVE AT(2) AGONIST, P-AMINOPHENYLALANINE(6) ANGIOTENSIN-II, ON THIRST AND SODIUM APPETITE IN RATS [J].
COONEY, AS ;
FITZSIMONS, JT .
EXPERIMENTAL PHYSIOLOGY, 1993, 78 (06) :767-774
[7]  
DENTON D. A., 1957, QUART JOUR EXPTL PHYSIOL, V42, P72
[8]  
FREGLY MJ, 1992, P SOC EXP BIOL MED, V199, P158
[9]   EFFECT OF A NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONIST, DUP-753, ON ANGIOTENSIN-RELATED WATER-INTAKE IN RATS [J].
FREGLY, MJ ;
ROWLAND, NE .
BRAIN RESEARCH BULLETIN, 1991, 27 (01) :97-100
[10]  
GHISSASSI ME, 1995, AM J PHYSIOL, V268, pR1401