Carotenoid and retinoid metabolism: insights from isotope studies

被引：41

作者：

Burri, BJ

Clifford, AJ ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA

[2] USDA ARS, Western Human Nutr Res Ctr, Davis, CA 95616 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2004年 / 430卷 / 01期

关键词：

carotenoid; isotope; human; rat; beta-carotene; vitamin A; lutein;

D O I：

10.1016/j.abb.2004.04.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Use of isotopes as tracers has had an important role in elucidating key features of vitamin A and retinoid metabolism in animal models and humans. Their use has shown that beta-carotene absorption is variable, and that the appearance of beta-carotene and its metabolites in the blood by time since dosing follows characteristic patterns. Retinol formed from beta-carotene shows a different pattern, as does lutein. In this article, we summarize and discuss insights and some surprises into the absorption and metabolism of vitamin A, beta-carotene, and lutein that were gained with the use of isotope tracers in humans, rats, and cells as models. (C) 2004 Elsevier Inc. All rights reserved,

引用

页码：110 / 119

页数：10

共 113 条

[1] PREDICTION OF LIVER VITAMIN-A IN RATS BY AN ORAL ISOTOPE-DILUTION TECHNIQUE [J].