UCP1 is essential for adaptive adrenergic nonshivering thermogenesis

被引:204
作者
Golozoubova, Valeria [1 ]
Cannon, Barbara [1 ]
Nedergaard, Jan [1 ]
机构
[1] Stockholm Univ, Wenner Gren Inst, Arrhenius Lab F3, SE-10691 Stockholm, Sweden
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2006年 / 291卷 / 02期
关键词
uncoupling protein-1; brown adipose tissue; norepinephrine; oxygen consumption; muscle thermogenesis; basal metabolic rate; BROWN ADIPOSE-TISSUE; COLD-ACCLIMATION; THYROID-HORMONE; FAT-CELLS; NORADRENALINE; MICE; ADRENALINE; CALORIGENESIS; ADIPOCYTES; HALOTHANE;
D O I
10.1152/ajpendo.00387.2005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Participation of brown adipose tissue [ through the action of the uncoupling protein-1 (UCP1)] in adaptive adrenergic nonshivering thermogenesis is recognized, but the existence of a response to adrenergic stimulation in UCP1-ablated mice implies that a mechanism for an alternative adaptive adrenergic thermogenesis may exist. Here, we have used UCP1-ablated mice to examine the existence of an alternative adaptive adrenergic nonshivering thermogenesis, examined as the oxygen consumption response to systemically injected norepinephrine into anesthetized or conscious mice acclimated to different temperatures. We confirm that UCP1-dependent adrenergic nonshivering thermogenesis is adaptive, but we demonstrate that the adrenergic UCP1-independent thermogenesis is not recruitable by cold acclimation. Thus, at least in the mouse, no other proteins or enzymatic pathways exist that can participate in or with time take over the UCP1 mediation of adaptive adrenergic nonshivering thermogenesis, even in the total absence of UCP1. UCP1 is thus the only protein capable of mediating cold acclimation-recruited adaptive adrenergic nonshivering thermogenesis.
引用
收藏
页码:E350 / E357
页数:8
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