Programming of neural cells by (endo) cannabinoids: from physiological rules to emerging therapies

被引：199

作者：

Maccarrone, Mauro ^{[1
,2
,3
]}

Guzman, Manuel ^{[4
,5
]}

Mackie, Ken ^{[6
]}

Doherty, Patrick ^{[7
]}

Harkany, Tibor ^{[8
,9
]}

机构：

[1] Campus Biomed Univ Rome, Sch Med, I-00128 Rome, Italy

[2] Campus Biomed Univ Rome, Ctr Integrated Res, I-00128 Rome, Italy

[3] European Ctr Brain Res, Santa Lucia Fdn, I-00143 Rome, Italy

[4] Univ Complutense Madrid, Dept Biochem & Mol Biol 1, E-28040 Madrid, Spain

[5] Univ Complutense Madrid, Ctr Invest Biomed Red Enfermedades Neurodegenerat, E-28040 Madrid, Spain

[6] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA

[7] Kings Coll London, Wolfson Ctr Age Related Dis, London SE1 1UL, England

[8] Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, SE-17177 Stockholm, Sweden

[9] Med Univ Vienna, Ctr Brain Res, Dept Mol Neurosci, A-1090 Vienna, Austria

来源：

NATURE REVIEWS NEUROSCIENCE | 2014年 / 15卷 / 12期

基金：

英国惠康基金; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

DIACYLGLYCEROL LIPASE-ALPHA; MESSENGER-RNA EXPRESSION; FOCAL ADHESION KINASE; LONG-TERM DEPRESSION; SUBVENTRICULAR ZONE; CB1; RECEPTORS; ENDOCANNABINOID SYSTEM; POSTNATAL-DEVELOPMENT; PRENATAL EXPOSURE; INDUCED APOPTOSIS;

D O I：

10.1038/nrn3846

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Among the many signalling lipids, endocannabinoids are increasingly recognized for their important roles in neuronal and glial development. Recent experimental evidence suggests that, during neuronal differentiation, endocannabinoid signalling undergoes a fundamental switch from the prenatal determination of cell fate to the homeostatic regulation of synaptic neurotransmission and bioenergetics in the mature nervous system. These studies also offer novel insights into neuropsychiatric disease mechanisms and contribute to the public debate about the benefits and the risks of cannabis use during pregnancy and in adolescence.

引用

页码：786 / 801

页数：16

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