Regulation of axonal development by plasma membrane gangliosides

被引：18

作者：

Abad-Rodriguez, Jose

Robotti, Andrea

机构：

[1] Catholic Univ Louvain, Flanders Interuniv Inst Biotechnol VIB11, Dept Mol & Dev Genet, B-3000 Louvain, Belgium

[2] Univ Turin, Fondaz Cavalieri Ottolenghi, Turin, Italy

来源：

JOURNAL OF NEUROCHEMISTRY | 2007年 / 103卷

关键词：

actin; axon; ganglioside; neurotrophins; plasma; membrane ganglioside sialidase/Neu3;

D O I：

10.1111/j.1471-4159.2007.04713.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gangliosides present in the plasma membrane participate in fundamental processes during neuronal development. From the determination and the outgrowth of the axon, to the growth inhibitory activity produced after CNS injury, local interconversion of these glycosphingolipids regulate actin dynamics in a spatially restricted manner by modulating membrane receptors and their downstream signaling pathways. Here, we will review the possible mechanisms underlying these modulations and the potential importance of gangliosides and ganglioside-transforming enzymes as therapeutic targets.

引用

页码：47 / 55

页数：9

共 85 条

[1] Neuronal membrane cholesterol loss enhances amyloid pepticle generation
Abad-Rodriguez, J
Ledesma, MD
Craessaerts, K
Perga, S
Medina, M
Delacourte, A
Dingwall, C
De Strooper, B
Dotti, CG
[J]. JOURNAL OF CELL BIOLOGY, 2004, 167 (05) : 953 - 960
[2] TACE-induced cleavage of NgR and p75NTR in dorsal root ganglion cultures disinhibits outgrowth and promotes branching of neurites in the presence of inhibitory CNS myelin
Ahmed, Zubair
Mazibrada, Gordon
Seabright, Ruth J.
Dent, Russell G.
Berry, Martin
Logan, Ann
[J]. FASEB JOURNAL, 2006, 20 (11) : 1939 - +
[3] Schwann cell-derived factor-induced modulation of the NgR/p75NTR/EGFR axis disinhibits axon growth through CNS myelin in vivo and in vitro
Ahmed, Zubair
Suggate, Ellen L.
Brown, Elspeth R.
Dent, Russell G.
Armstrong, Stephanie J.
Barrett, Lee B.
Berry, Martin
Logan, Ann
[J]. BRAIN, 2006, 129 : 1517 - 1533
[4] Synaptic function of cholinergic-specific chol-1α ganglioside
Ando, S
Tanaka, Y
Kobayashi, S
Fukui, F
Iwamoto, M
Waki, H
Tai, T
Hirabayashi, Y
[J]. NEUROCHEMICAL RESEARCH, 2004, 29 (04) : 857 - 867
[5] p75NTR is positively promiscuous: Novel partners and new insights
Barker, PA
[J]. NEURON, 2004, 42 (04) : 529 - 533
[6] Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism
Cai, DM
Shen, YJ
De Bellard, M
Tang, S
Filbin, MT
[J]. NEURON, 1999, 22 (01) : 89 - 101
[7] GANGLIOSIDES POTENTIATE INVIVO AND INVITRO EFFECTS OF NERVE GROWTH-FACTOR ON CENTRAL CHOLINERGIC NEURONS
CUELLO, AC
GAROFALO, L
KENIGSBERG, RL
MAYSINGER, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (06) : 2056 - 2060
[8] Asymmetric membrane ganglioside sialidase activity specifies axonal fate
Da Silva, JS
Hasegawa, T
Miyagi, T
Dotti, CG
Abad-Rodriguez, J
[J]. NATURE NEUROSCIENCE, 2005, 8 (05) : 606 - 615
[9] RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability
Da Silva, JS
Medina, M
Zuliani, C
Di Nardo, A
Witke, W
Dotti, CG
[J]. JOURNAL OF CELL BIOLOGY, 2003, 162 (07) : 1267 - 1279
[10] Breaking the neuronal sphere: Regulation of the actin cytoskeleton in neuritogenesis
Da Silva, JS
Dotti, CG
[J]. NATURE REVIEWS NEUROSCIENCE, 2002, 3 (09) : 694 - 704

← 1 2 3 4 5 6 7 8 9 →