Phenolic marine natural products as aldose reductase inhibitors

被引:78
作者
Manzanaro, Sonia
Salva, Javier
de la Fuente, Jesus Angel [1 ]
机构
[1] SA Poligono Ind, Inst Biomar, Edifico CEEI, Leon 24231, Spain
[2] Univ Cadiz, Fac Ciencias Mar, Dept Quim Organ, Cadiz 11510, Spain
来源
JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 10期
关键词
D O I
10.1021/np0503698
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Four different types of marine natural compounds isolated from tunicates were found to inhibit human aldose reductase. They all are characterized by a heterocyclic system, and at least two phenolic groups are present in the structure. Two of the compounds tested showed an inhibitory potency 5/6-fold higher than that of the known AR inhibitor sorbinil. One notable structural feature of these active compounds is the lack of either the carboxylic acid or the spiro-hydantoin commonly present in the principal classes of currently used inhibitors.
引用
收藏
页码:1485 / 1487
页数:3
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