Phenolic marine natural products as aldose reductase inhibitors

被引：78

作者：

Manzanaro, Sonia

Salva, Javier

de la Fuente, Jesus Angel ^{[1
]}

机构：

[1] SA Poligono Ind, Inst Biomar, Edifico CEEI, Leon 24231, Spain

[2] Univ Cadiz, Fac Ciencias Mar, Dept Quim Organ, Cadiz 11510, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 10期

关键词：

D O I：

10.1021/np0503698

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four different types of marine natural compounds isolated from tunicates were found to inhibit human aldose reductase. They all are characterized by a heterocyclic system, and at least two phenolic groups are present in the structure. Two of the compounds tested showed an inhibitory potency 5/6-fold higher than that of the known AR inhibitor sorbinil. One notable structural feature of these active compounds is the lack of either the carboxylic acid or the spiro-hydantoin commonly present in the principal classes of currently used inhibitors.

引用

页码：1485 / 1487

页数：3

共 31 条

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