Cytotoxic metabolites from an Australian collection of the sponge Jaspis species

被引：49

作者：

Groweiss, A ^{[1
]}

Newcomer, JJ ^{[1
]}

O'Keefe, BR ^{[1
]}

Blackman, A ^{[1
]}

Boyd, MR ^{[1
]}

机构：

[1] NCI, Frederick Canc Res & Dev Ctr, Lab Drug Discovery Res & Dev, Dev Therapeut Program,Div Canc Treatment & Diagno, Frederick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 12期

关键词：

D O I：

10.1021/np9902688

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new natural products, bengamide Y (1), bengamide Z (3), and bengazole Z (5), were isolated from the aqueous extract of an Australian collection of the sponge Jaspis sp. Their structures were solved by spectroanalytical methods and by comparison of their spectral data with known bengamides and bengazoles that were reported from the same genus. Bengamides Y (1) and Z (3) showed a striking differential cytotoxicity pattern against a panel of 10 human tumor cell lines, with closely related cell lines (e.g., SNB-19 and SNB-75) displaying significant differences in sensitivity.

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页码：1691 / 1693

页数：3

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