Independent controls for neocortical neuron production and histogenetic cell death

被引:83
作者
Verney, C
Takahashi, T
Bhide, PG
Nowakowski, RS
Caviness, VS
机构
[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurol, Boston, MA USA
[2] Hop La Pitie Salpetriere, INSERM, U106, Paris, France
[3] Keio Univ, Sch Med, Dept Pediat, Tokyo, Japan
[4] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, Piscataway, NJ 08854 USA
关键词
cell death; apoptosis; cell cycle; cell proliferation; TUNEL; neocortex;
D O I
10.1159/000017434
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We estimated the proportion of cells eliminated by histogenetic cell death during the first 2 postnatal weeks in areas 1, 3 and 40 of the mouse parietal neocortex. For each layer and for the subcortical white matter in each neocortical area, the number of dying cells per mm(2) was calculated and the proportionate cell death for each day of the 2-week interval was estimated, The data sh ow th at cell death proceeds essentially uniformly across the neocortical areas and layers and that it does not follow either the spatiotemporal gradient of cell cycle progression in the pseudostratified ventricular epithelium of the cerebral wall, the source of neocortical neurons, or the 'inside-out' neocortical neuronogenetic sequence. Therefore, we infer that the control mechanisms of neocortical histogenetic cell death are independent of mechanisms controlling neuronogenesis or neuronal migration but may be associated with the ingrowth, expansion and a system-wide matching of neuronal connectivity. Copyright (C) 2000 S. Karger AG, Basel.
引用
收藏
页码:125 / 138
页数:14
相关论文
共 73 条
  • [41] MCSHERRY GM, 1984, J EMBRYOL EXP MORPH, V81, P239
  • [42] MCSHERRY GM, 1986, J ANAT, V144, P1
  • [43] RELATIONSHIP OF THE TIME OF ORIGIN AND DEATH OF NEURONS IN RAT SOMATOSENSORY CORTEX - BARREL VERSUS SEPTAL CORTEX AND PROJECTION VERSUS LOCAL CIRCUIT NEURONS
    MILLER, MW
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1995, 355 (01) : 6 - 14
  • [44] Mione MC, 1997, J NEUROSCI, V17, P2018
  • [45] MIONE MC, 1994, J NEUROSCI, V14, P107
  • [46] Gradient in the duration of the G1 phase in the murine neocortical proliferative epithelium
    Miyama, S
    Takahashi, T
    Nowakowski, RS
    Caviness, VS
    [J]. CEREBRAL CORTEX, 1997, 7 (07) : 678 - 689
  • [47] OLEARY DDM, 1994, ANNU REV NEUROSCI, V17, P419, DOI 10.1146/annurev.neuro.17.1.419
  • [48] OPPENHEIM RW, 1991, ANNU REV NEUROSCI, V14, P453, DOI 10.1146/annurev.ne.14.030191.002321
  • [49] Separate Progenitor Cells Give Rise to Pyramidal and Nonpyramidal Neurons in the Rat Telencephalon
    Parnavelas, J. G.
    Barfield, J. A.
    Franke, E.
    Luskin, M. B.
    [J]. CEREBRAL CORTEX, 1991, 1 (06) : 463 - 468
  • [50] Polleux F, 1997, J NEUROSCI, V17, P7763