共 21 条
- [21] Synthesis of the C1′-C11′ segment of leucascandrolide A[J]. JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (09) : 3242 - 3245Wipf, PGraham, TH
Synthesis of the C1′-C11′ oxazole-containing side chain of leucascandrolide A.: Application of a sonogashira cross-coupling
被引：53
作者：
Dakin, LA
Langille, NF
Panek, JS
机构：
[1] Boston Univ, Metcalf Ctr Sci & Engn, Dept Chem, Boston, MA 02215 USA
[2] Boston Univ, Metcalf Ctr Sci & Engn, Ctr Streamlined Synth, Boston, MA 02215 USA
关键词：
D O I：
10.1021/jo0204000
中图分类号：
O62 [有机化学];
学科分类号：
070303 ;
081704 ;
摘要：
An efficient, convergent synthesis of the C1'-C11' side chain (3) of leucascandrolide A (1) has been achieved. The key bond connection is made through the use of a palladium(0)-catalyzed Sonogashira cross-coupling between trifloyl oxazole (4) and alkynylmetal species (5).
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页码：6812 / 6815
页数：4
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