How important is protein kinase C in μ-opioid receptor desensitization and morphine tolerance?

被引：83

作者：

Bailey, Chris P.

Smith, Forrest L.

Kelly, Eamonn

Dewey, William L.

Henderson, Graeme ^{[1
]}

机构：

[1] Univ Bristol, Dept Pharmacol, Bristol BS8 1TD, Avon, England

[2] Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2006年 / 27卷 / 11期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.tips.2006.09.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The repeated administration of opiate drugs such as morphine results in the development of tolerance to their analgesic, rewarding (euphoric) and respiratory-depressant effects; thus, to obtain the same level of response with subsequent administrations, a greater dose must be used. Tolerance can limit the clinical efficacy of opiate drugs and enhance the social problems that are inherent in recreational opioid abuse. Surprisingly, the mechanism (or mechanisms) underlying the development of morphine tolerance remains controversial. Here, we propose that protein kinase C could have a crucial role in the desensitization of mu-opioid receptors by morphine and that this cellular process could contribute to the development and maintenance of morphine tolerance in vivo.

引用

收藏

页码：558 / 565

页数：8

相关论文

共 82 条

[31] PKC and PKA inhibitors reverse tolerance to morphine-induced hypothermia and supraspinal analgesia in mice [J].

Javed, RR ;

Dewey, WL ;

Smith, PA ;

Smith, FL .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 492 (2-3) :149-157

[32] Agonist-selective mechanisms of μ-opioid receptor desensitization in human embryonic kidney 293 cells [J].

Johnson, Elizabeth A. ;

Oldfield, Sue ;

Braksator, Ellen ;

Gonzalez-Cuello, Ana ;

Couch, Daniel ;

Hall, Kellie J. ;

Mundell, Stuart J. ;

Bailey, Chris P. ;

Kelly, Eamonn ;

Henderson, Graeme .

MOLECULAR PHARMACOLOGY, 2006, 70 (02) :676-685

[33] The role of opioid receptor phosphorylation and trafficking in adaptations to persistent opioid treatment [J].

Johnson, Emma E. ;

Christie, MacDonald J. ;

Connor, Mark .

NEUROSIGNALS, 2005, 14 (06) :290-302

[34] Receptor endocytosis counteracts the development of opioid tolerance [J].

Koch, T ;

Widera, A ;

Bartzsch, K ;

Schulz, S ;

Brandenburg, LO ;

Wundrack, N ;

Beyer, A ;

Grecksch, G ;

Höllt, V .

MOLECULAR PHARMACOLOGY, 2005, 67 (01) :280-287

[35]

Kovoor A, 1998, MOL PHARMACOL, V54, P704

[36]

Kramer HK, 1999, J NEUROCHEM, V72, P585

[37] The role of receptor kinases and arrestins in G protein-coupled receptor regulation [J].

Krupnick, JG ;

Benovic, JL .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1998, 38 :289-319

[38] Protein kinase c-e is responsible for the protection of preconditioning in rabbit cardiomyocytes [J].

Liu, GS ;

Cohen, MV ;

Mochly-Rosen, D ;

Downey, JM .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1999, 31 (10) :1937-1948

[39] INCREASES IN PROTEIN KINASE-C-GAMMA IMMUNOREACTIVITY IN THE SPINAL-CORD OF RATS ASSOCIATED WITH TOLERANCE TO THE ANALGESIC EFFECTS OF MORPHINE [J].

MAO, JR ;

PRICE, DD ;

PHILLIPS, LL ;

LU, J ;

MAYER, DJ .

BRAIN RESEARCH, 1995, 677 (02) :257-267

[40] Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene [J].

Matthes, HWD ;

Maldonado, R ;

Simonin, F ;

Valverde, O ;

Slowe, S ;

Kitchen, I ;

Befort, K ;

Dierich, A ;

LeMeur, M ;

Dolle, P ;

Tzavara, E ;

Hanoune, J ;

Roques, BP ;

Kieffer, BL .

NATURE, 1996, 383 (6603) :819-823

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