An easy deoxygenation of conjugated epoxides

被引：23

作者：

Righi, G ^{[1
]}

Bovicelli, P ^{[1
]}

Sperandio, A ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Chem, CNR, Ctr Studio Chim Sostanze Organ Nat, I-00185 Rome 62, Italy

来源：

TETRAHEDRON | 2000年 / 56卷 / 12期

关键词：

oxiranes; deoxygenation; isomerisation;

D O I：

10.1016/S0040-4020(99)01083-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An easy and high yielding transformation of epoxyketones and phenyl substituted epoxides to trans olefins in a convergent diastereoselective process is reported. The method was applied to the selective C-25 hydroxy-functionalisation of 3-keto-Delta(4)-cholestan-3-one, a key intermediate for the synthesis of C-25 hydroxy vitamin D-3. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1733 / 1737

页数：5

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