Nucleic acid triple helices: Stability effects of nucleobase modifications

被引：54

作者：

Robles, J

Grandas, A

Pedroso, E

Luque, FJ

Eritja, R

Orozco, M

机构：

[1] Univ Barcelona, Fac Quim, Dept Quim Organ, E-08028 Barcelona, Spain

[2] Univ Barcelona, Fac Farm, Dept Fisicoquim, E-08028 Barcelona, Spain

[3] CSIC, Inst Biol Mol Barcelona, ES-08034 Barcelona, Spain

[4] Univ Barcelona, Fac Quim, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain

来源：

CURRENT ORGANIC CHEMISTRY | 2002年 / 6卷 / 14期

关键词：

D O I：

10.2174/1385272023373482

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the last years DNA triplexes have been the subject of a very intense research effort, which has been summarized in a vast number of books and reviews (see for example refs. [1-16]). After a general introduction to DNA polymorphism and the structure of triple helices, we will examine here general approaches to the stabilization of triple helices. Methods based in external binding to DNA and backbone modification will be briefly summarized, and the reader will be addressed to more specific reviews. Finally, we will survey strategies for triplex stabilization based on modification of nucleobases, paying particular attention to recent advances in the field.

引用

页码：1333 / 1368

页数：36

共 452 条

[61]

CHANDLER SP, 1995, BIOCHEMISTRY-US, V34, P15338

[62] Stabilization of triple-stranded oligonucleotide complexes: Use of probes containing alternating phosphodiester and stereo-uniform cationic phosphoramidate linkages [J].