Cubic phases of gangliosides in water: Possible role of the conformational bistability of the headgroup

被引：33

作者：

Boretta, M ^{[1
]}

Cantu, L ^{[1
]}

Corti, M ^{[1
]}

delFavero, E ^{[1
]}

机构：

[1] UNIV MILAN,IST NAZL FIS MAT,I-20133 MILAN,ITALY

来源：

PHYSICA A | 1997年 / 236卷 / 1-2期

关键词：

gangliosides; cubic phases; X-ray scattering;

D O I：

10.1016/S0378-4371(96)00406-2

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

An accurate X-ray scattering study of the self-association properties in water of the ganglioside GM1, a biological amphiphile similar to phospholipids but with an oligosaccharide headgroup, is described. The phase diagram displays a large cubic region, for concentrations between 31% and 55% by weight, enclosed by isotropic micellar and lamellar phases. The peculiar feature of the GM1 molecule to present a conformational bistability, recently observed in ganglioside micelles, can be well recognized in the cubic phase region, suggesting that GM1-water behaves like a pseudoternary system, with an additional degree of freedom, automatically readjusting the mole fraction of the two conformers in order to optimize the molecular packing.

引用

页码：162 / 176

页数：15