SQUARE -: determining reliable regions in sequence alignments

被引：16

作者：

Tress, ML ^{[1
]}

Graña, O ^{[1
]}

Valencia, A ^{[1
]}

机构：

[1] CSIC, CNB, Madrid 28049, Spain

来源：

BIOINFORMATICS | 2004年 / 20卷 / 06期

关键词：

D O I：

10.1093/bioinformatics/bth032

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The Server for Quick Alignment Reliability Evaluation (SQUARE) is a Web-based version of the method we developed to predict regions of reliably aligned residues in sequence alignments. Given an alignment between a query sequence and a sequence of known structure, SQUARE is able to predict which residues are reliably aligned. The server accesses a database of profiles of sequences of known three-dimensional structures in order to calculate the scores for each residue in the alignment. SQUARE produces a graphical output of the residue profile-derived alignment scores along with an indication of the reliability of the alignment. In addition, the scores can be compared against template secondary structure, conserved residues and important sites.

引用

页码：974 / 975

页数：2

共 7 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].