Behavioral and biochemical studies of dichloromethane fraction from the Areca catechu nut

被引：104

作者：

Dar, A ^{[1
]}

Khatoon, S ^{[1
]}

机构：

[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Pharmacol Sect, Karachi 75270, Pakistan

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2000年 / 65卷 / 01期

关键词：

Areca catechu; dichloromethane fraction; antidepressant; synaptosomes; 5-hydroxytryptamine; monoamine oxidase-A;

D O I：

10.1016/S0091-3057(99)00179-3

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The dichloromethane fraction from Areca catechu was found to inhibit monoamine oxidase type A isolated from the rat brain with an IC50 of 665 +/- 65.1 mu g/ml. Studies with pharmacological models of depression, i.e., forced swim and tail-suspension tests, indicated that ii caused significant reduction in the immobility time similar to that of moclobemide (a selective inhibitor of MAO-A) without causing a significant change in motor performance. Alkaloids such as arecaidine, arecoline, and a few other constituents, reported to be present in Areca catechu were also tested, but none of them were found to inhibit MAO. Present study suggests that the dichloromethane fraction from A. catechu possesses antidepressant property via MAO-A inhibition. (C) 1999 Elsevier Science Inc.

引用

页码：1 / 6

页数：6

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