Cognitive deficits in Parkinson's disease: A cognitive neuroscience perspective

被引：203

作者：

Robbins, Trevor W. ^{[1
,2
]}

Cools, Roshan ^{[3
,4
]}

机构：

[1] Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England

[2] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England

[3] Radboud Univ Nijmegen Med Ctr, Donders Inst Brain Cognit & Behav, Dept Psychiat, Nijmegen, Netherlands

[4] Radboud Univ Nijmegen Med Ctr, Ctr Cognit Neuroimaging, Nijmegen, Netherlands

来源：

MOVEMENT DISORDERS | 2014年 / 29卷 / 05期

基金：

英国惠康基金;

关键词：

striatum; prefrontal cortex; executive function; attention; dopamine; memory; cognition; FRONTAL-LOBE DYSFUNCTION; BASAL GANGLIA; PREFRONTAL CORTEX; DOPAMINERGIC MEDICATION; VISUOSPATIAL MEMORY; NUCLEUS-ACCUMBENS; ACTION SELECTION; WORKING-MEMORY; ALZHEIMER-TYPE; DEMENTIA;

D O I：

10.1002/mds.25853

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Progress in characterization of the nature, neural basis, and treatment of cognitive deficits in Parkinson's disease is reviewed from the perspective of cognitive neuroscience. An initial emphasis on fronto-striatal executive deficits is surveyed along with the discoveries of disruption as well as remediation of certain impairments by dopaminergic mediation and their association with theories of reinforcement learning. Subsequent focus on large cohorts has revealed considerable heterogeneity in the cognitive impairments as well as a suggestion of at least two distinct syndromes, with the dopamine-dependent fronto-striatal deficits being somewhat independent of other signs commonly associated with Parkinson's disease dementia. The utility is proposed of a new, integrated cognitive neuroscience approach based on combining genetic and neuroimaging methodologies with neuropsychological and, ultimately, psychopharmacological approaches. (c) 2014 International Parkinson and Movement Disorder Society

引用

页码：597 / 607

页数：11

共 111 条

[1]

A systematic review of prevalence studies of dementia in Parkinson's disease [J].

Aarsland, D ;

Zaccai, J ;

Brayne, C .

MOVEMENT DISORDERS, 2005, 20 (10) :1255-1263

[2]

Aberrant reward processing in Parkinson's disease is associated with dopamine cell loss [J].

Aarts, Esther ;

Helmich, Rick C. ;

Janssen, Marcel J. R. ;

Oyen, Wim J. G. ;

Bloem, Bastiaan R. ;

Cools, Roshan .

NEUROIMAGE, 2012, 59 (04) :3339-3346

[3]

PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX [J].

ALEXANDER, GE ;

DELONG, MR ;

STRICK, PL .

ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 :357-381

[4]

Neural systems engaged by planning: A PET study of the Tower of London task [J].

Baker, SC ;

Rogers, RD ;

Owen, AM ;

Frith, CD ;

Dolan, RJ ;

Frackowiak, RSJ ;

Robbins, TW .

NEUROPSYCHOLOGIA, 1996, 34 (06) :515-526

[5]

Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action [J].

Balleine, Bernard W. ;

O'Doherty, John P. .

NEUROPSYCHOPHARMACOLOGY, 2010, 35 (01) :48-69

[6]

The debate over dopamine's role in reward: the case for incentive salience [J].

Berridge, Kent C. .

PSYCHOPHARMACOLOGY, 2007, 191 (03) :391-431

[7]

Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinsons patients [J].

Bodi, Nikoletta ;

Keri, Szabolcs ;

Nagy, Helga ;

Moustafa, Ahmed ;

Myers, Catherine E. ;

Daw, Nathaniel ;

Dibo, Gyoergy ;

Takats, Annamaria ;

Bereczki, Daniel ;

Gluck, Mark A. .

BRAIN, 2009, 132 :2385-2395

[8]

Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease - An in vivo positron emission tomographic study [J].

Bohnen, NI ;

Kaufer, DI ;

Ivanco, LS ;

Lopresti, B ;

Koeppe, RA ;

Davis, JG ;

Mathis, CA ;

Moore, RY ;

DeKosky, ST .

ARCHIVES OF NEUROLOGY, 2003, 60 (12) :1745-1748

[9]

BOLLER F, 1984, ARCH NEUROL-CHICAGO, V41, P485, DOI 10.1001/archneur.1984.04050170031011

[10]

Staging of brain pathology related to sporadic Parkinson's disease [J].

Braak, H ;

Del Tredici, K ;

Rüb, U ;

de Vos, RAI ;

Steur, ENHJ ;

Braak, E .

NEUROBIOLOGY OF AGING, 2003, 24 (02) :197-211

← 1 2 3 4 5 6 7 8 9 10 →