Spindle regulation in neural precursors of flies and mammals

被引：50

作者：

Buchman, Joshua J.

Tsai, Li-Huei ^{[1
]}

机构：

[1] MIT, Howard Hughes Med Inst, RIKEN,Neurosci Res Ctr, Dept Brain & Cognit Sci,Picower Inst Learning & M, Cambridge, MA USA

[2] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2007年 / 8卷 / 02期

关键词：

D O I：

10.1038/nrn2058

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mitotic spindle is the cellular scaffold that facilitates proper segregation of genetic material during cell division. Far from being static, the spindle is a dynamically regulated tool that can alter its size, shape and position during mitosis. Work in both insect and vertebrate systems has shown that regulation of this structure involves an array of highly conserved proteins. Moreover, it is now clear that tight regulation of the spindle during the process of neurogenesis is paramount to proper cell division and generation of the nervous system as a whole.

引用

页码：89 / 100

页数：12

共 136 条

[1] Loss of occludin and functional tight junctions, but not ZO-1, during neural tube closure - Remodeling of the neuroepithelium prior to neurogenesis [J].

AakuSaraste, E ;

Hellwig, A ;

Huttner, WB .

DEVELOPMENTAL BIOLOGY, 1996, 180 (02) :664-679

[2]

Adams RJ, 1996, J NEUROSCI, V16, P7610

[3] PAR3 acts as a molecular organizer to define the apical domain of chick neuroepithelial cells [J].

Afonso, Cristina ;

Henrique, Domingos .

JOURNAL OF CELL SCIENCE, 2006, 119 (20) :4293-4304

[4] Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry [J].

Albertson, R ;

Doe, CQ .

NATURE CELL BIOLOGY, 2003, 5 (02) :166-170

[5]

AUSTIN CP, 1995, DEVELOPMENT, V121, P3637

[6] The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila [J].

Bello, Bruno ;

Reichert, Heinrich ;

Hirth, Frank .

DEVELOPMENT, 2006, 133 (14) :2639-2648

[7] Selective interaction of AGS3 with G-proteins and the influence of AGS3 on the activation state of G-proteins [J].

Bernard, ML ;

Peterson, YK ;

Chung, P ;

Jourdan, J ;

Lanier, SM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (02) :1585-1593

[8] Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells [J].

Betschinger, J ;

Mechtler, K ;

Knoblich, JA .

CELL, 2006, 124 (06) :1241-1253

[9] The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl [J].

Betschinger, J ;

Mechtler, K ;

Knoblich, JA .

NATURE, 2003, 422 (6929) :326-330

[10] Dare to be different:: Asymmetric cell division in Drosophila, C-elegans and vertebrates [J].

Betschinger, J ;

Knoblich, JA .

CURRENT BIOLOGY, 2004, 14 (16) :R674-R685

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