Spindle regulation in neural precursors of flies and mammals

被引：50

作者：

Buchman, Joshua J.

Tsai, Li-Huei ^{[1
]}

机构：

[1] MIT, Howard Hughes Med Inst, RIKEN,Neurosci Res Ctr, Dept Brain & Cognit Sci,Picower Inst Learning & M, Cambridge, MA USA

[2] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2007年 / 8卷 / 02期

关键词：

D O I：

10.1038/nrn2058

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mitotic spindle is the cellular scaffold that facilitates proper segregation of genetic material during cell division. Far from being static, the spindle is a dynamically regulated tool that can alter its size, shape and position during mitosis. Work in both insect and vertebrate systems has shown that regulation of this structure involves an array of highly conserved proteins. Moreover, it is now clear that tight regulation of the spindle during the process of neurogenesis is paramount to proper cell division and generation of the nervous system as a whole.

引用

页码：89 / 100

页数：12

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