Multipotent Flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages

被引：537

作者：

Kattman, Steven J. ^{[1
]}

Huber, Tara L. ^{[1
]}

Keller, Gordon M. ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, Black Family Stem Cell Inst, Dept Gene & Cell Med, New York, NY 10029 USA

来源：

DEVELOPMENTAL CELL | 2006年 / 11卷 / 05期

关键词：

D O I：

10.1016/j.devcel.2006.10.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell-tracing studies in the mouse indicate that the cardiac lineage arises from a population that expresses the vascular endothelial growth factor receptor 2 (VEGFR2, Flk-1), suggesting that it may develop from a progenitor with vascular potential. Using the embryonic stem (ES) cell differentiation model, we have identified a cardiovascular progenitor based on the temporal expression of the primitive streak (PS) marker brachyury and Flk-1. Comparable progenitors could also be isolated from head-fold stage embryos. When cultured with cytokines known to function during cardiogenesis, individual cardiovascular progenitors generated colonies that displayed cardiomyocyte, endothelial, and vascular smooth muscle (VSM) potential. Isolation and characterization of this previously unidentified population suggests that the mammalian cardiovascular system develops from multipotential progenitors.

引用

页码：723 / 732

页数：10

共 53 条

[31]

LINTS TJ, 1993, DEVELOPMENT, V119, P419

[32] Inhibition of Wnt activity induces heart formation from posterior mesoderm [J].