Parasympathetic neurons originate from nerve-associated peripheral glial progenitors

被引：167

作者：

Dyachuk, Vyacheslav ^{[1
,2
]}

Furlan, Alessandro ^{[1
]}

Shahidi, Maryam Khatibi ^{[3
]}

Giovenco, Marcela ^{[1
]}

Kaukua, Nina ^{[4
]}

Konstantinidou, Chrysoula ^{[5
]}

Pachnis, Vassilis ^{[5
]}

Memic, Fatima ^{[1
]}

Marklund, Ulrika ^{[1
]}

Mueller, Thomas ^{[6
]}

Birchmeier, Carmen ^{[6
]}

Fried, Kaj ^{[4
]}

Ernfors, Patrik ^{[1
]}

Adameyko, Igor ^{[7
]}

机构：

[1] Karolinska Inst, Dept Med Biochem & Biophys, Mol Neurobiol Unit, Stockholm, Sweden

[2] Russian Acad Sci, AV Zhirmunsky Inst Marine Biol, Far Eastern Branch, Vladivostok 690022, Russia

[3] Karolinska Inst, Dept Dent Med, Stockholm, Sweden

[4] Karolinska Inst, Dept Neurosci, Stockholm, Sweden

[5] Med Res Council MRC Natl Inst Med Res, Div Mol Neurobiol, London, England

[6] Max Delbruck Ctr Mol Med, Dept Neurosci, Berlin, Germany

[7] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden

来源：

SCIENCE | 2014年 / 345卷 / 6192期

基金：

瑞典研究理事会; 欧洲研究理事会;

关键词：

NEURAL CREST; DIFFERENTIATION; SPECIFICATION; MELANOCYTES; CELLS; ERBB2;

D O I：

10.1126/science.1253281

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The peripheral autonomic nervous system reaches far throughout the body and includes neurons of diverse functions, such as sympathetic and parasympathetic. We show that the parasympathetic system in mice-including trunk ganglia and the cranial ciliary, pterygopalatine, lingual, submandibular, and otic ganglia-arise from glial cells in nerves, not neural crest cells. The parasympathetic fate is induced in nerve-associated Schwann cell precursors at distal peripheral sites. We used multicolor Cre-reporter lineage tracing to show that most of these neurons arise from bi-potent progenitors that generate both glia and neurons. This nerve origin places cellular elements for generating parasympathetic neurons in diverse tissues and organs, which may enable wiring of the developing parasympathetic nervous system.

引用

页码：82 / 87

页数：6

共 20 条

[1]

Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest [J].