A renaissance in herbal medicine identification: From morphology to DNA

被引：371

作者：

Chen, Shilin ^{[1
,2
,3
]}

Pang, Xiaohui ^{[1
,2
]}

Song, Jingyuan ^{[1
,2
]}

Shi, Linchun ^{[1
,2
]}

Yao, Hui ^{[1
,2
]}

Han, Jianping ^{[1
,2
]}

Leon, Christine ^{[4
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China

[2] Peking Union Med Coll, Beijing 100193, Peoples R China

[3] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

[4] Royal Bot Gardens, Richmond TW9 3AB, Surrey, England

来源：

BIOTECHNOLOGY ADVANCES | 2014年 / 32卷 / 07期

基金：

中国国家自然科学基金;

关键词：

DNA barcode; Plant authentication; Adverse reactions; Safety; ITS2; psbA-trnH; ARISTOLOCHIC ACID; SPECIES IDENTIFICATION; LAND PLANTS; PLASTID GENOME; BARCODE; AUTHENTICATION; SEQUENCES; SYSTEM; LIFE; RBCL;

D O I：

10.1016/j.biotechadv.2014.07.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Numerous adverse reactions have arisen following the use of inaccurately identified medicinal plant ingredients, resulting in conditions such as aristolochic acid nephropathy and herb-induced poisoning. This problem has prompted increased global concern over the safety of herbal medicines. DNA barcoding, a technique aiming at detecting species-specific differences in a short region of DNA, provides a powerful new tool for addressing this problem. A preliminary system for DNA barcoding herbal materials has been established based on a two-locus combination of ITS2 + psbA-trnH barcodes. There are 78,847 sequences belonging to 23,262 species in the system, which include more than 95% of crude herbal drugs in pharmacopeia, such as those of China, Japan, Korea, India, USA, and Europe. The system has been widely used in traditional herbal medicine enterprises. This review summarizes recent key advances in the DNA barcoding of medicinal plant ingredients (herbal materia medica) as a contribution towards safe and efficacious herbal medicines. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：1237 / 1244

页数：8

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