Homochiral α-D- and β-D-isoxazolidinylthymidines via 1,3-dipolar cycloaddition

被引：74

作者：

Chiacchio, U

Corsaro, A

Gumina, G

Rescifina, A

Iannazzo, D

Piperno, A

Romeo, G

Romeo, R

机构：

[1] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy

[2] Univ Messina, Dipartimento Farmacochim, Messina, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 26期

关键词：

D O I：

10.1021/jo990576a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The introduction of chiral auxiliaries at the C- or N-atom in starting nitrones has been investigated as a stereoselective synthetic route to heterocyclic nucleoside analogues. The carbohydrate auxiliary at nitrogen atom gave the best results, thus allowing an easy and enantioselective synthesis of isoxazolidinyl thymine 26.

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页码：9321 / 9327

页数：7

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