HPV typing in Brazilian patients with epidermodysplasia verruciformis: High prevalence of EV-HPV 25

被引:37
作者
de Oliveira, WRP
He, Q
Rady, PL
Hughes, TK
Neto, CF
Rivitti, EA
Tyring, SK
机构
[1] Univ Sao Paulo, Dept Dermatol, Sao Paulo, Brazil
[2] Univ Texas, Dept Immunol Microbiol, Med Branch, Galveston, TX 77555 USA
[3] Univ Texas, Ctr Hlth Sci, Dept Dermatol, Houston, TX USA
关键词
D O I
10.1177/120347540400800206
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background. Epidermodysplasia verruciformis is a rare genetic disorder characterized by development of lesions associated with HPV#5 or HPV#8 in early childhood, malignant transformation occurs in approximately half of individuals during adulthood. Objective: Our goal was to study the presence and spectrum of EV-HPV types in Brazilian EV patients, a population that had never been studied in this regard. Patients and MethodsForty-one biopsies from different lesions (benign and skin tumors) and one biopsy from clinically normal skin from each of 20 Brazilian patients with EV were studied for HPV typing using nested PCR. Results: EV-HPV DNA was detected in all 41 skin lesions of the patients and was also identified in specimens considered as normal skin from 8 patients (40%). In this study HPV-EV 25 was the most prevalent (70%), and HPV 14d (67%) was highly associated with malignant lesions. Conclusion: EV-HPV 25 was the most prevalent in our study. The noteworthy association of EV-HPV type 14d with skin cancers suggests its possible oncogenic role in malignant transformation in this population.
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收藏
页码:110 / 115
页数:6
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