Functional role of TRPC proteins in vivo:: lessons from TRPC-deficient mouse models

被引：48

作者：

Freichel, M ^{[1
]}

Vennekens, R ^{[1
]}

Olausson, J ^{[1
]}

Hoffmann, M ^{[1
]}

Müller, C ^{[1
]}

Stolz, S ^{[1
]}

Scheunemann, J ^{[1
]}

Weissgerber, P ^{[1
]}

Flockerzi, V ^{[1
]}

机构：

[1] Univ Saarland, D-66421 Homburg, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 322卷 / 04期

关键词：

TRPC proteins; agonist-activated Ca2+ entry; mouse models; integrative physiology; pheromone sensing; vascular tone; endothelial permeability; GABA release; thalamus; blood pressure; myogenic tone;

D O I：

10.1016/j.bbrc.2004.08.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to elucidate the functional role of TRPC genes, in vivo, the targeted inactivation of these genes in mice is an invaluable technique. In this review, we summarize the currently available results on the phenotype of TRPC-deficient mouse lines. The analysis of mice with targeted deletion in three TRPC genes demonstrates that these proteins represent essential constituents of agonist-activated and phospholipase C-dependent Ca2+ entry channels in primary cells. Furthermore, from the deficits observed in these TRPC-deficient mouse lines a striking number of biological functions could already be ascribed to TRPC2, TRPC4, and TRPC6, not only on the cellular level but also for complex organ functions and integrative physiology. Accordingly, TRPC2 proteins are critically involved in pheromone sensing by neurones of the vomeronasal organ and, thereby, in the regulation of sexual and social behavior of mice, TRPC4 proteins are essential determinants of endothelial-dependent regulation of vascular tone, endothelial permeability, and neurotransmitter release from thalamic interneurones, and TRPC6 proteins are supposed to have a fundamental role in the regulation of smooth muscle tone in blood vessels and lung. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1352 / 1358

页数：7

共 47 条

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